Sulik is your first NPC. You'll have to pay his debts ($250 or $300, depends on situation, thanx to Jade for this tip) to get him, or you can get him for free if you free trapper Smiley. He's usually a must have (if you're a melee character, you won't need him since it is better to take sniper chars). He can carry a lot until you find a car, and can do a heavy damage with Super Sledge Hammer (not to mention how good he is "cleaning" the area). Since he'll spend almost all the time in first combat line, it is good to give him a good armor.
Note: Sulik cannot be slaver. If you are, he'll attack you.

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It would be good to keep Vic in your party, because later he can be very useful, since he can use Gauss rifle, which is excellent against Enclave soldiers. his repair skill may come in handy if you're not good with tools. But, in order to get him, you'll have to pay $1000 to Metzger (or $500 if you're a female and decide to do something with Metzger), or just kill the shit slaver!

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If you sleep with her, you'll get married. Not very good in anything, small amount of hit points is a good chance for you to be a widow/widower.

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Miria's bisexual brother. Total waste of NPC slot if you ask me. He is somewhat good with knifes, but again, can someone of his caliber help you against the Enclave? So, if you're a slaver, sell him.

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He's a must have. Give him Gauss rifle and combat is 50% easier! Due to his heart problems, it is not recommended to use drugs on him or he'll die. It is interesting that he can use drugs, if you leave him some in inventory.
Note: Sometimes, his skill will change to Melee, if you give him Powered armor. It'll be back to normal again after one or 2 levels.

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Lenny can be very useful if you give him the best SMG in the game. He is also good because he can take a lot of damage instead of you.

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This one is my favorite. Mutant Sheriff of Broken Hills. If you're a melee character, give him Plasma Rifle. If you're a sniper, give him either Rocket Launcher or a mini gun. He's great, but cannot wear armors. Oh yes, he's not sterile anymore :)

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Basically, Myron sucks in combat. He has a 30% to hit, and sometimes, he can do extensive damage if he hit Marcus. Once, the damage was 58 HPs with Gauss Pistol! Anyway, he's good for science use, he can create stimpaks and super stimpacks.

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Character of this robot depends on brain you put into him. At least I think so :) So, I'm unable to state anything about him, because I placed abnormal brain and got a science robot, that refused to fight! On the other hand, some people got him to fight with small guns skill, and say that he is the best NPC in game.

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He's a good boy, but he always troubled me. He never hit someone for a good damage, and if you have Marcus, it could be a problem if he fires a burst and K-9 is near :)

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Deathclaw is a great companion. Take a look at his damage! Cannot use armors or weapons.

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Basically, an average NPC, but if you're up to have a dog in your squad, I think there is a better one.

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Have you played Fallout 1? Thanx you must know who this is. This is everyone's favorite NPC from Fallout 1 :) Note: Cafe is a random encounter in wasteland.