Fallout 2 had many examples of this. Apparently there seems to be some kind of racism against ghouls and mutants, a lot of people fail to realize that ghouls and mutants are humans too. Vault City refused entry for mutants or ghouls and any human who showed even the slighted sign of mutation. Broken Hills had those conspiring to destroy the mutants. And then there was the Enclave's plot to kill off all mutants and impure humans on the mainland. And as the Chosen One can say to Dick Richardson, mutants are simply a better form of humans. And to Charlie Curling, that mutants are another form of human. It's just like real life society's intolerance towards people who are "different". As Marcus puts it, "what is it people got against mutants?"