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Well, oihrebwe is correct, that is the "point of no return" but basically, without the world changed a lot, except a few more guys standing around...
Indeed. The list I have for the leveling system is basically (in ideas so far). Level cap: This should be a lot higher, 40 is a good...
The Brotherhood perhaps? Who knows what has really happened since 2077, what factions have come and gone etc, some must have been friendly....