Few bugs I encountered in my playthrough 2.47.8:
Navarro Marisa bugged (talking to her crashes the game, rewriting script from previous version fixed this)
NCR Elise (Ranger girl) - when sent on mission against slavers, ended in another location (not slaver camp, but farm)
The Glow - killing...
Caves in random encounters are bugged for me. When I enter, camera is centered somewhere where I am not and cannot be scrolled on the party. Hitting home button does this. Cannot move the screen more up to see the party.
Changing resolution, any settings in ddraw etc did not help me.
According...
Encounter same bug just today. Replace data\scripts\SCENLONE.int with file from older release for workaround fix (I was able to download 2.44 somewhere)