A Spiritual Successor is more likely to happen thou.
A VtMB successor might also be one of the secret projects at Obsidian since most of Troinka is with them.
Temple of Elemental Evil: Best DnD game IMO.
Red Alert 1 & 2
Persona 1-3: All of them need a full remake with updated gameplay and graphics, something similar to Persona 4 Golden but for PC and Switch as well.
SMT Nocturne
System Shock 2
Rome Total War
Fallout 1 and 2