I've been playing two games in parallel, alternating between these two characters:
Lucky
Female
ST: 5
PE: 10
EN: 2
CH: 4
IN: 10
AG: 6
LK: 10
Gifted, Finesse; Tag Speech, Traps, and Doctor
Warrior
Male
ST: 8
PE: 8
EN: 1
CH: 2
IN: 10
AG: 10
LK: 1
Heavy Handed, Fast Shot; Tag Speech, Doctor, Unarmed
The really low endurance is my latest thing. It adds a real challenge, especially early. Tagging Traps helped Lucky a lot, because of the trap room in the Temple of Trials. Basically I level up that much faster at the beginning. Also, not tagging normal things like Lockpick means that I spend a ton of skill points on that skill. Then, later I pick the Tag! perk and get a truck load of skill points all at once at a time in the game when it's very helpful. And some would say that ST:8 is a waste because of perks and armor, but I dig it. Being able to wail on geckos early on is so satifjying!
I also like playing the two characters/games in tandem because then I get the chance to approach situations differently and compare.