Yes, I did so the other day.
You can only do about 1 quest in each town, so you can play through the game relatively quickly. For example, in San Fransisco, all you have to do is infiltrate the navarro base and steel the vertibird plans, then the Brotherhood of Steel guy will fuel up the tanker and set the destination for you, and you can get to the oil rig. You don't have to mess with hubologists or the shi, although you can raise your intellegence by one if let the hubologists make you watch a video.
You should be extremely buff at the end of the game, since you will have to take on Frank by yourself.
Some of the quests seem buggy. After I beat the Khans, I couldn't talk to tandi, even though they told me I could. I guess the intellegence was to low to get past gunther, or whoever is in the tuxedo.
The dialogue throughout the game is pretty damn funny.