Pandemic-causing 'Asian flu' accidentally released
The virus that caused the 1957 “Asian flu” pandemic has been accidentally released by a lab in the US, and sent all over the world in test kits which scientists are now scrambling to destroy.
There are fears the virus could escape the labs, as the mistake was discovered after the virus escaped from a kit at a high-containment lab in Canada. Such an escape could spread worldwide, as demonstrated in Russia in the 1970s.
The flu testing kits were sent to some 3700 labs between October 2004 and February 2005 by the College of American Pathologists (CAP), a professional body which helps pathology laboratories improve their accuracy, by sending them unidentified samples of various germs to identify.
The CAP kits - prepared by private contractor Meridian Bioscience in Cincinnati, US - were to contain a particular strain of influenza A - the viral family that causes most flu worldwide. But instead of choosing a strain from the hundreds of recently circulating influenza A viruses, the firm chose the 1957 pandemic strain.
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A few of the CAP kits were sent to labs in Asia, the Middle East and South America, as well as Europe and North America. The kits’ originators had to know what they contained, in order to evaluate the test results. However, when Canada’s National Microbiology Lab in Winnipeg identified the strain on 26 March, it alerted the US Centers for Disease Control and the World Health Organization. Worryingly, it initially found the potentially deadly virus in a sample unrelated to the test kit - meaning it had already escaped within the lab.
Test kits for flu are not handled at a high level of biological containment as it is generally assumed they do not carry unusually dangerous viruses. But its escape in the Winnipeg lab is worrying, as the lab contains facilities with the highest level of containment and its staff is expected to maintain high levels of lab hygiene. Its most probable route of escape into the outside world would be if a lab worker catches the Asian flu, then passes it on.
But there has been no sign of the virus infecting humans yet, says Klaus Stöhr, chief flu scientist at the World Health Organization in Geneva. But as the usual northern flu season is just ending it is not clear if any cases would have been noticed.
“If this incident doesn't cause a major reassessment of the safety of flu research, a lab-sponsored pandemic may well be the only thing that induces sobriety,” comments Ed Hammond of the Sunshine Project, a biosafety pressure group.
