Probably. Below is a part of the patch readme, read it and decide for yourself:
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In addition to fixing many minor script bugs, this patch fixes the following problems:
- You can no longer get duplicate copies of the same NPC in your party.
- Armor now correctly adjusts your stats when being moved around in your inventory.
- Surviving exposure to radiation no longer raises your stats.
- The autorun program will no longer attempt to load while the game is playing.
This patch will not invalidate your saved games, however any saved game which has already been corrupted will not be fixed by installing this patch. For example, if you have a saved game which contains the duplicate-NPC bug, loading that saved game after installing this patch will not remove the duplicate NPC's from your party.
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That's it.