Honestly, in my opinion, this sort of DLC is dead when the G.E.C.K drops. That's it. You're finished. Modders can make whatever you can make at a faster and less-expensive option. Hell, they even did half of the content of this thing before-hand.
What modders don't have is voice acting. Voice acting can't be added by making some models and making magic out of the game. Voice acting needs the proper equipment and actors to be really good. Most mods (surprise) don't have this.
New Vegas Bounties?
http://www.nexusmods.com/newvegas/mods/37310/?
Shit voice acting. (By Bethesda's standards)
I'll admit they did pretty good for what they had, but it's got nothing on what Bethesda's got. Seriously, Brian T. Delany is really good at his job.
This is not bad news, trust me. This means Bethesda will be forced to make
Story focused quests and worlds and the lore that goes with it.
We might get to see something good from Bethesda! What about another Pitt-like DLC? Fallout 3 wasn't that great, Pitt DLC was the bomb! Fallout 4 wasn't that great, Pitt-like DLC = bomb!
Just trying to stay optimistic.