In overall the patch correct a lot bugs in many quests, like Camp McCarran (finally that PoS Contreras is usable), Melissa works correct this time, Motor Runner don't bug anymore and so on.
I didn't like the fact that a lot of recipes in firecamps became extremelly easy to be made, they nerfed A LOT of them. The poisons are extremelly easy to craft now.
Also people will now swim in caps more than ever, since Gecko hides are also nerfed, it's very easy to do them.
Dynamic Herbalism is a must now.
The worst part however in my opinion is that you have a NON-FACTION T51-b power armor in the BoS safehouse.
I usually don't use power or heavy armor, since they punish your agility or movement a lot, but I think is too much let you have acess to this type of armor early in the game.
Before the patch you really have to work to own a non-faction power armor.
People are complaining a lot about the snipers, but I think Obsidian did the right thing, it was obscene the amount of damage they done.
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