Just stop in the square before the Glow, pop two Rad-X, and move in. Make sure you have a rope, can't believe how many times I've forgotten to get some (embarassing, I know). As long as you've at least got Metal Armor, an Assault Rifle (JHP ammo, not AP) and decent Repair skill the glow shouldn't be any trouble.
As Graz'zt said, if you're too weak for the Glow the endgame is going to eat you alive.