The movie begins with the showing of original footage from some of the 311 nuclear tests that were carried out by the U.S. government in the desert of New Mexico during the years 1945-1992. The government had ordered the local residents to move so they wouldn't get hurt by the atomic tests. But some of the residents (miners) refused to leave their homes, and were exposed to dangerous levels of radiation. The miners went to the mines and survived, but their newborn children were genetically altered. The children are now adults, and to survive in the desert, they murder and rob tourists going through the desert. They are not only insane murderers, but they have become blood-thirsty cannibals. The Carter family has an accident in the desert, and they are about to become the next victims. However, Big Bob Carter, (Ted Levine), a retired police detective, isn't going to let that happen.