Golbolco
Still Mildly Glowing

It's more than completely doable, all that limits people is imagination and willingness to be faithful to either source. There must be a level of compromise, but that is easy.That’s easier said than done. The two timelines are not truly compatible and share many characters that are almost the same but not quite. Van Buren’s Legion is more technologically advanced than the one in New Vegas. Speaking of that place, it’s not even mentioned in Van Buren, raising questions about its existence or importance. I think it was only mentioned once in Fallout 1, simply referred to as 'Vegas.' Additionally, some major events that occurred in Van Buren never happened in the official timeline, particularly regarding San Francisco and Shady Sands.
We tried to consolidate the timelines for Fallout Yesterday back in 2014 but failed. There were lots of issues but you’re welcome to try of course.
To quote Tagaziel, an ex-admin of Fallout wiki:
“Trying to reconcile Van Buren and New Vegas, which are mutually exclusive, is an exercise in futility. The sooner you realize that, the better.”
Unfortunately, the Fallout fandom's creativity coffers have been drained as of late, but you will find many ideas and projects on this forum and elsewhere that rewrite NV to fit with VB or rewrite VB to fit with NV. I'll offer my own when it's ready.