No Mutants Allowed

If you can play a more combat focus with less intelligent dialogue and world building FNV, then go for it.
You can always take the train and play in FNV when you get bored, of course, you will have to be able to reach the train station and activate the power for it to work (without mods) if you start in Vault 101.

I would probably just use the CW as a stress reliever, barely engage in quests, maybe test some mods there.

Just a note:
FO3 mods need to be converted to work with TTW and some FNV mods might need a patch to affect the CW.