They are only worth it if you depend a lot on VATS. I almost never use VATS so I never pick any of them. But if you depend on VATS a lot, then I guess they might be worth it.
Although I still consider perks that just increase the chance to hit in VATS a bit useless. depending on how fast you increase your weapon skill you might max it by level 10 or less (depends on other factors like Intelligence, skill books used, tagged skills, perks that increase skill points gain, etc) and you can't increase the VATS chance over 95% even with the perks, so while they might be useful to hit enemies at low levels, it will reach a point where those perks will not be doing anything anymore because your weapon skill will already give you the 95% to hit or quite close to that.
I guess the Center of mass perk would still be useful at any level if you use VATS and target the torso.
The perk for VATS I recommend (again, only if you use VATS a lot) is the Grim Reaper's Sprint, because when you are fighting several enemies at once and depend on VATS gaining 20 AP for free is quite helpful (in FO3 that perk is even OP, since it makes you fill up all the AP).