As I mentioned in your other thread: "Season to taste". Whatever works for you is what's best.
That being said, however, aimed shots are NOT very tedious at all. Yes, you gotta target each time you take a shot, but ONLY if you want to make targeted shots. You can still fire without aiming, and your character will aim for the torso, which has the highest chance to hit. But provided your combat skill is high enough (or you're patient enough and can tolerate missing a few times), targeted shots REALLY pay off, and can make combat much, MUCH quicker than a character with Fast Shot can.
Shots to the Eyes have the best chance of immediately killing an opponent, but they are the hardest to hit. Shots to the Head are effective and quite likely to knock your target unconscious, so you can ignore them for the rest of a fight while you deal with other enemies (possibly knocking them out, one by one, too). Shots to the Groin do very little damage, but VERY likely to knock out your target, and it's much easier to land a Groin shot than a Head shot or aiming for the Eyes. If an enemy is using ANY 2-handed weapon, you can make them useless if you aim for one of their arms and successfully cripple it. If an enemy tries to flee from you (you said you're playing the RP, and there's ONE particularly nasty guy who runs away you'd probably want to take out before he escapes) then aiming for the legs will make them a sitting duck.
I made a full conversion from Fast Shot Sniper to Targeted Shot Sniper, and I played FO2 DOZENS of times with Fast Shot characters, so it's not to say that it isn't really, really fun. But some parts of the game are just INCREDIBLY tedious if you can't target your shots. Becoming a Heavyweight Champion is very easy when you can constant punch boxers in the nuts for an easy knockout. ^^