The first time I shot a wanamingo to pieces with a Bozar. My first walkthrough was as a charismatic smart-alec so I was terrified of those. Then I built up a nice Big Guns character and went to clean up the mines. Wanamingos have a rather nice "death by big guns" special animation. Kinda felt like the guy riding the nuke in Dr. Strangelove then.
Also, the ghoul bartender in Gecko telling his severed head story. No idea why, but that was hilarious.