Ahhh sometimes I do so enjoy Jinxed:
"Hey! You! No weapons in here!"
[wait about 5 seconds]
[Combat begins]
'Gizmo's Guard critically missed, dropped his weapon and lost his next turn.'

This of course applies to Super Mutants and the like as well...
Pro tip: Jinxed plus Kamikaze and a maxed Perception (EDIT: and Luck) stat, if you're willing to abandon some other traits for these two, makes for a lot of fun.
EDIT: For those that don't remember off the top of their head:
So you want to max out Perception as soon as possible because this increases your chance to hit (thus indirectly lowering chance to get those bad critical failures)
"Hey! You! No weapons in here!"
[wait about 5 seconds]
[Combat begins]
'Gizmo's Guard critically missed, dropped his weapon and lost his next turn.'

This of course applies to Super Mutants and the like as well...
Pro tip: Jinxed plus Kamikaze and a maxed Perception (EDIT: and Luck) stat, if you're willing to abandon some other traits for these two, makes for a lot of fun.
EDIT: For those that don't remember off the top of their head:


So you want to max out Perception as soon as possible because this increases your chance to hit (thus indirectly lowering chance to get those bad critical failures)