I listened to a good deal of it while I was doing some other activities, but I kinda of tuned out a bit so I don't remember very much, although he didn't say much that was particularly novel or unexpected so that might have been part of the reason. Here's a breakdown of some of the stuff come to mind:
* He says that one ingredient to make combat more fun is by making the NPCs really stupid. He says that they could be made to be far much smarter than they are on Bethesda games, but that would make it too hard for players to defeat them and that would make the game less fun.
* Regarding character creation, he says that many people criticize Bethesda for simplifying the newer iterations of their games far too much (i.e. removing stats and classes, etc..), but he says that they didn't simplify they just moved specialization choices to further down the game so that players aren't stuck with a character they don't like if they make poor choices during character creation (frankly I think that this is a lie because Skyrim never gets as complex or intricate as Morrowind no matter how deep you are in the game).
* Regarding the differences between TES and Fallout, he says that he sees Fallout as a more tongue-in-cheek and comedic game whereas TES is supposed to be more serious.
* He only has a general idea of when TES6 is coming out, not even internally do they have an exact date set (he didn't specify further though).
* Regarding quests and missions, he says that he enjoys it when they are open ended and have more than one solution. He cites as an example an quest where a character has to collect 5 daedric hearts, saying that it can be just as interesting as a more tighly structured and designed quest because there are many different ways in which the player can acquire the hearts.
* Can't remember much else honestly.