DwayneGAnd
Look, Ma! Two Heads!

Seeing as how it's possible to maximize all skills, a level 50 courier could probably use weapons from all five combat skills. Heck, why not, if you're maxing all your skills, might as well put them to good use. Seeing as how most couriers use guns, energy weapons, unarmed, or melee for a primary attack, together with explosives as a secondary attack, I would recommend only using one from the other three.
My suggestions are:
Guns
This Machine
Sleepytime
Nailgun
Energy Weapons
Pew Pew
Laser RCW
Elijah's Advanced LAER
Melee Weapons
Thermic Lance (for high strength characters with plenty of carry weight to spare only)
Chainsaw (same)
Oh Baby (same)
Ripper
Chance's Knife (for grunts)
Blood Nap (for cowboys)
Unarmed
Ballistic Fist
Industrial Hand
Pushy
Comments, opinions, and suggestions welcome!
My suggestions are:
Guns
This Machine
Sleepytime
Nailgun
Energy Weapons
Pew Pew
Laser RCW
Elijah's Advanced LAER
Melee Weapons
Thermic Lance (for high strength characters with plenty of carry weight to spare only)
Chainsaw (same)
Oh Baby (same)
Ripper
Chance's Knife (for grunts)
Blood Nap (for cowboys)
Unarmed
Ballistic Fist
Industrial Hand
Pushy
Comments, opinions, and suggestions welcome!