I didn't really understand what you were trying to say.
E=mc2, so it doesn't matter whether there is energy or matter.
The two things are interchangeable.
From relativistic view point that is true. From a practical/Newtonian view point it is not. The concept of a vacuum was contrived under (pre)Newtonian physics, when most people think of a vacuum, and when a vacuum is considered for any practical purpose invariant mass
is used. So whilst it is, sort of true - on a practical basis it is not. Hence why i said 'Not really' (because i knew someone would pwn me ). You can theoretically have a region of space devoid of any invariant mass, this is in keeping in what the word 'vacuum' essentially means.