Yep, Both. In fact, IIRC on the Spybot homepage they advise that you use Ad-Aware too.
As for the sacrifice e-mail, i do that too. It means that all the spam that i get (~30 e-mails a day) goes there, wheras the only "Spam" i get to my main addy are offers from Amazon.co.uk (which i use regularly enyway) and things like that.
EDIT- I also use Spyware Blaster (from wilders security http://www.wilders.org/) which kind of immunises your system against any spyware.
As for the sacrifice e-mail, i do that too. It means that all the spam that i get (~30 e-mails a day) goes there, wheras the only "Spam" i get to my main addy are offers from Amazon.co.uk (which i use regularly enyway) and things like that.
EDIT- I also use Spyware Blaster (from wilders security http://www.wilders.org/) which kind of immunises your system against any spyware.