If there was an entire settlement of No Barks however then it would be ridiculous.
Bethesda: "That sounds great! Write that shit down, Emil!"
Whackyness when it's a secondary thing must be like the caramelized fruit in cakes. It's a bit meh just on its own, and it complements the cake well. But it can also be removed with no major grade losses of the core for the people that don't like it.
Good examples of this were FNV and at a lesser extent Fo2. The first literally has a switch and it can even possibly be removed later on. The second, while not optable, in no moment is told to you with a straight face. And it's not that much in the way nor major plot points. You might never see nothing of that by accident, or see every single one. Adds a bit to the experience of "what the fuck is this world?".
Same goes for Borderlands, IMO. While I dislike BL2's bombradment of pop culture references, at times in the series they have some actually pretty smart and that are the cherry on top of a weird post-apoc plus cyberpunk setting. Next day, you are being played in a P&P campaign of a fantasy version of the main game's plot. Other shocking Interplanetary Ninja Assasin Claptrap. Or being the only attendant to his birthday.
Other games that handle it well are Terraria, where you fight goblins, pirates, aliens, orcs, demons, dragons, Chutulu's... parts, huge animals, snowmen, etcetera with swords that throw nyancat-like projectiles, use a rock metal electric guitar, piss on mobs, or have your army of bees, tiki and drones to do the job. It's incoherent fantasy, and it embodies it.
It's needless to say who and what does it bad. Y'know. Synth gorillas.