I was playing Fallout 4 on survival mode, level 12 if I do remember well (a bee can kill you). I've found a damm Super Mutant Patrol, and started running. A lot. I've found a strange house made of junk, with a single npc living in it. This npc was a barter, with nothing great to exchange.
Minutes later, I've heard the super mutants yelling. God dammit! I've rushed inside the house, shitting on my pants. All I heard was mutants yelling, and I was on sneak, "o shit, oh shit, oh shit!". Then, A grenade exploded outside. I was so freaked out, that the grenade sounded like a nuclear blast.
I've waited, waited, the silence, and the mutants were gone. I've spotted one walking away, and the barter npc, dead.
Survival is the way to play.