Slaughter Manslaught
Vault Senior Citizen
For me it would consist of the Fallout setting including all the depth of characterization and dialogue with a better combat system that allows for more tactics and group management, like the one from Jagged Alliance 2. S.P.E.C.I.A.L would only have to be modified a bit in the AP department. It would also incorporate the destructible environments from Silent Storm.
Please stop reading my mind.
Maybe a Mad Max RPG/FPP/TPP hybrid? And no, it's not Fallout 3. I mean Mad Max. All the Mad Maxy awesomeness. Vehicle battles, chases, fighting using crossbows, bows, melee weapons, your own fists and maybe even the rare gun you come across!