What about doing a default/canon Courier.
-Default character
-S.P.E.C.I.A.L is arbitrary,but I'd have it as 5 in everything but Luck, which would be 10. Ideally you'd have everything at 5.
-Skills are again arbitrary, but I'd choose Guns, Survival and maybe Barter or Speech.
-Vault 21 Jumpsuit (Install mod/console command that adds armored vault-suit.)
-Wild-Card
-Neutral/Good Karma (Your choice)
-Generally cowboy themed weaponry (I'd throw in some "iconic" and "gimmick" weapons in there too, like ARCHIMEDES and perhaps the Holorifle.)
-Try to recruit all companions throughout the game, swapping them out throughout the game. ED-E should be your primary companion
-Try to complete as many quests as possible.
-Nuke both the NCR and the Legion at the end of Lonesome Road.
I dunno, I'm not so great at "theme" characters. I'm better at specific personalities.
That one's pretty good for a "default" Courier. I've done a similar run, but with 10 in Intelligence rather than Luck, and with my main weapon being a modded hunting rifle and the main armor the Desert Ranger outfit from Honest Hearts (swapped out for the Lonesome Road riot gear at the end).
Seriously, I need help with a nerd RP. mostly addictions if any, and choices for some quests.
You could try an Unarmed/Melee Mad Scientist build. A unique combination of Nerdiness, Brutality and Criminal Tendencies.
Starting SPECIAL: High Endurance and Intelligence. Low Charisma, and roleplay this aspect accordingly.
Tag!: Unarmed, Science, Medicine
Secondary Skills: Sneak, Survival, Melee. Or consider Explosives and Repair go down the Mad Bomber route.
Equipment: Power Fist/Pushy/Saturnite Fist/Ballistic Fist should be your primary weapon. A Zap Glove or the Paladin Toaster for pesky robots and the BoS (whom you despise). If you want to use explosives, stick with homemade, Mad Bomber grenades or C-4 exclusively.
Perks: Nerd Rage, All Chem related perks, plus the usual ones for an unarmed build. Terrifying Presence to make threats.
Chems: You're a discerning narcotics user, and enjoy multiple drug cocktails. Specifically, you like Slasher + Psycho + MedEx, or the Mentats + Buffout combination. You can also brew up Party Time Mentats and use them to supplement your extremely low Charisma.
Main Quest: Mr. House or Yes Man. Maybe you'll be satisfied with a role as a brutal enforcer for Mr. House, respecting both his scientific knowledge and his political acumen and knowing that he'll ensure a comfortable life and steady supply of drugs for you. Or maybe you'll play along with House up to the very end, then stab him in the back and take over Vegas for yourself. Alternatively, you could join forces with Elijah (Dead Money DLC required).
Background: You grew up rough on the streets of a gritty frontier town in the NCR, where you learned how to brawl. But in spite of these humble beginnings, your intelligence and uncanny good luck brought you to the attention of one of the local outposts of the Followers of the Apocalypse. Impressed by your natural talent, they took you in, gave you a good education. Under the Followers care, you embarked on a rigorous course of medical and scientific training. However, you never really left behind the ethics of the street, and never really bought into the Followers' philosophy, and so you were eventually kicked out of the organization for "self-medicating" and brewing and selling chems on the side.
As a rogue scientist, you then turned to seedier scientific pursuits, serving as a chemist, computer tech and emergency surgeon for a string of gangs and crime families across the NCR. During this time, you refined your Tag! skills, as well as your taste for illegal chems. But as the years went by and the NCR's power became more consolidated, it has become harder to find dishonest work, with all of your employers eventually winding up imprisoned or dead at the hands of the Rangers. To survive, you had to keep moving, your brains and your brawn keeping you just one step ahead of the law. Eventually, finding yourself down on your luck, you moved to the furthest edge of the frontier and took a temporary job as a courier, hoping that in the lawless environment of the Mojave, you'd find a use for your skills...
Playstyle You can solve quests using your intelligence, your scientific skills, or your fists, but generally not by sweet-talking people. You are an extremely antisocial, arrogant brainiac, personality wise. If you have to talk to people who are less intelligent than you are, you very much prefer being under the influence of chems. You can raise Speech to 70 in order to get Terrifying Presence, and use this to threaten people if you like, but otherwise don't spend too many points on Speech or Barter.
Factions: You strongly identify with and respect the power-hungry geniuses of the Mojave, like Mr. House, Elijah, the Think Tank, and even Caesar. That doesn't necessarily mean you'll side with them, or hesitate to kill them if it comes to that, but you
respect them.
You think the Followers are naive fools and dislike the Brotherhood of Steel for their medieval social structure and fetishistic attitude towards technology.
You really, really,
really hate the NCR because of your criminal background. You will not work with the NCR and will take every opportunity to avoid them, and will strike out at them if you have the chance. There's no way you're letting them take the Mojave.
As a former Follower, you have a grudging admiration for Caesar and his accomplishments, and as a pugilist, you can respect the fighting prowess of his Praetorian Guard. But as a scientist, a professional drug supplier and serious drug user you would
never want to live under his technologically primitive puritanical regime. You don't harbor the same resentment toward them that you have for the NCR, but you are, ultimately, an enemy of the Legion.
Like the other gangs you've worked with in the past, you don't really
respect the Powder Gangers, Khans, or Fiends, but you find them to be useful, and you may seek out employment with them or run quests for them if it suits your purposes.
Companions: ED-E is a natural choice and his long range laser can complement your close quarters combat style. Beyond that, it's up to you.