I'm excited for it, we get the engine to make a pretty immersive world. Say what you will about the other aspects of Fallout 3, when it was done right I felt more immersed in first person going though stuff in Fallout 3, than I did in the old isometric view.
If they can fix special, BALANCE the damn XP gain. Unmodded its just ridiculous. Now with all the dlc the whole damn game needs to be rebalanced, I really don't think they planned ahead, or had no clue on how game flow was gonna work. Because Fallout 3 starts out trying to be "Black Isle'd" by sticking skill checks here and there but that largely goes out the window when you no longer have to min/max anything and can be master of all around level 18, and definitely by 30. Its like they started out trying to stay nearer to Fallout and then just went "aw fuckit lets go Oblivion in here!"
So hopefully Obsidian can plan ahead, I know the writing will be better, but I don't know if the animation will be that great. Does Obsidian have anyone from Troika? IMO Vampire: Bloodlines still has the best voice acting, and facial animations, I've seen in a PC game. A lot probably had to do with the lip sync tech that is in the source engine, but it still was pretty incredible.
I have more faith in Fallout: N.V., than Alpha Protocol.... I'm still siting on KoToR 2 unplayed, waiting for Team Gizka to finish their restoration project.