Sad to report EPA is crashing for me in the same way, second playthrough in a row. I only have Nirran's perks per level installed on top of RP 3.2. The first time I enter EPA everything is fine, but if I leave at any point every time I try to come again it crashes. That was in the first playtrough, in this playthrough I decided to stay for the first time, but if I save the game at EPA, the game crashes upon loading. Also, the plant spray canisters don't seem to be working.
EDIT: I just tried entering the map, leaving, then immediately going back in. Crash. I'll try to sneak into the bottom level, see what happens.
I also managed to get the card for the red level from the hologram in armor but it crashed as I took the elevetor up.
EDIT2: I tried it all again, and I could load a game I saved on lvl 4, and while doing the quest for the female hologram I could take the elevator to lvl3 (back up). But after having visited floor 6 or having the red keycard the game crashes when I try to go to floor 3.
EDIT3: More testing - I managed to do all the hologram quests except the one which gives codes to doors (for the female hologram) by acessing the W wing through the poisonus room. I'll see if another crash happens when I do the female hologram's quest.
EDIT4: Crashed after I've freed Jules and tried to take the elevator to the 3rd floor. Correction - crashed after I killed the aliens, disabled the force field and found out I need the gel to free Jules. That was enough to get it to crash either elevator.
EDIT5: Went back up a save game to when I got the password for the seventh floor - crash when trying to go to lvl 3.
Anyway, the error report I got after turning off the high res patch reads: "The instruction at 10044f61 referenced memory at 0052ff46. The memory could not be written". Sadly that's all I've got...