RPGamer conducted a Q&A with Emil Pagiarulo at E3:<blockquote>When asked about whether or not it'd be possible to kill any and all NPCs, Emil expressed their concern over letting their players get backed into a corner that they can't get themselves out of, or not experiencing content the designers want to be sure they see. So it's currently still being worked out whether or not they'll be able to design the game such that they can let you kill whoever, or if they'll have to make some people untouchable. He did express a strong desire to have as few unkillable NPCs as possible, as they know the negative aspects of putting walls like that in front of players.
The player's gender does affect the reactions of NPCs, opening up different conversations and quests and whatnot. However, at this time they could not confirm whether there would be any romantic affairs available.
Once again, a question about who the target audience is resulted in the response that the target audience is Bethesda. He reiterated that their design strategy is to make the game that they want to play.</blockquote>Link: Fallout 3 Q&A with Emil Pagliarulo at RPGamer.
Spotted on BethBlog.
The player's gender does affect the reactions of NPCs, opening up different conversations and quests and whatnot. However, at this time they could not confirm whether there would be any romantic affairs available.
Once again, a question about who the target audience is resulted in the response that the target audience is Bethesda. He reiterated that their design strategy is to make the game that they want to play.</blockquote>Link: Fallout 3 Q&A with Emil Pagliarulo at RPGamer.
Spotted on BethBlog.