I dunno, whenever I play, its sort of a wash. Like helping vault city is good, but in a way bad in the long run, since it stays independant and ends up hurting everything by jealously keeping its tech to itself. When I go to new reno, I help the writes since they seem like the good guys, but you find out thier just as bad as the rest, the only difference is thier family is actually, you know, a family. I normally end up being "Good" because most of the quest outcomes tend to award good karma, though even if doing something awards good karma, generally i won't do it if I dont like it. Case in point some of the quests involving the shi in san-fran. I just don't trust those buggers. Niether do I trust the hubbologist, but you lost karma when you kill them in random encounters.