I haven't finished the game, any of the faction quests, or most of the DLC quests. I think Automatron is the only one that I completed, because it's short, and at least Beth was trying to have fun. They're better when they fail at comedy than when they fail being dramatic or intellectual. IMO, failed humor is usually just awkward or bland.
The funny thing is that I've progressed a fair way into most of the big quests, but I have restartitus and I tend to try to install mods to fix things, restart, then spend hours exploring and building up the new character. So I have over a hundred hours in. Twice now I've gotten to the point where I was overwhelmed by the stupid, and uninstalled the game.
Ironically, reading these forums occasionally tempts me to reinstall and try to finish the game again, or at least a couple of quest lines. But then I remember the pain.