(In a dull, robotic tone) The. Glow. Is. An. A.ma.zing. Lo.ca.tion. It. Is. A. Ma.ster.piece. In. Terms. Of. Narr.a.tive. And. Am.bi.ance. It. Is. The. Most. Mem.or.a.ble. Lo.ca.tion. In. All. Of. Fall.out.
.....
Okay, that's enough out of that gag. But seriously, the Glow IS a pretty stellar location, as far as the mood and memorable experiences go, but it's got way more to it than that. More so than the logs you can download to your Pipboy at Mariposa, The Glow's background will shed the most light on what happened in the Core Region that led it to what it has become today... in a very dark and foreboding way. If you didn't know about any of the cut content from the game, one of the holodisks in particular is pretty freaky.
But I'd say that all "advice" regarding The Glow should fall under a few categories: You haven't been there yet / You've been there before.
You haven't been to The Glow yet: Save your game before you start your journey, because the trek is long and arduous, and if you haven't recovered the Water Chip yet, every day is precious, so you'll want a save to revert back to where you didn't eat up 50 days in a single venture that maybe didn't go as well as you'd anticipated. Once you arrive (assuming you brought a particular item of great necessity that keeps popping up repeatedly throughout the game), enjoy the experience! You won't need to go far to find what you're looking for, and you won't melt simply by showing up; there's time you can explore before you become fatally irradiated, and even then you can be saved by taking breaks on your journey back.
You've already been to The Glow before: It's always worth it to go in every run. Simply put, compared to the rest of the game where resources are either scarce or claimed, there's no better place to scavenge than The Glow. If your version of the game doesn't have the Infinite Mule glitch patched, then you can walk away from it having picked it clean with only Ian at your side, and even if you have a version where that's addressed (FIXT) you can still carry out everything you left behind on later trips after you've acquired your Power Armor. The biggest threats that The Glow poses become trivial once you've been there before, even if you don't know the "tricks" to reduce them into pointless. I personally arrive on the grid directly Northwest of The Glow and pop 2 Rad-X pills, then enter the grid itself, and I explore and leave The Glow behind having absorbed ZERO radiation; it's that gimmicky. There's also only 1 floor where the robots will actually be fighting you (I don't even need to disable the inactive ones, I just enter combat and destroy them before I turn the power back on) and by the time you reach it you'll have already scavenged some good stuff that will buff up your chances, assuming your chances weren't real high to begin with. Getting eviscerated by the security shouldn't be a problem. Getting fatally irradiated shouldn't be a problem. Getting EVERYTHING out and pawned off back at The Hub shouldn't be a problem. So yes, it's worth it to visit The Glow. =)