It really depends on what you want to hear.
If you like pixies and fairies and magical stuff that doesn't make sense but keeps you from the worries of free thought:
Yes, there is an afterlife. If you live your life by following an arbitrary set of moral standards, you'll go to heaven and/or be saved by Jesus/Moses/Tarzan/Some guy in a skirt, and all will be fine, because you will experience eternal happiness without ever having to worry about your mortal problems.
Alternatively, no, life is the mess we are put through before we get the final reward of omniscience and, ironically, non-existance, by becoming one with everything and/or ceasing to exist. If you screw up, you come back and have to endure it all over again, probably as a lesser lifeform.
If you want the sober version without the magic, which actually gives you the burden of responsibility:
No, there is no life after death. At least not in the sense any major religion came up with so far. When you die, your conciousness slowly fades away after an incredibly uplifiting dream your brain creates whenever it suffers from severe loss of oxygen (the so-called "near death experience", which can be reproduced through severe physical stress resulting in unconciousness through sudden loss of oxygen). After that, your conciousness has ceased to exist and your body, if not kept functional through artificial means, will begin to decompose only to eventually cease to exist as well.
In this case, there's really not much I can tell you to make death look like a particularily fun thing to look forward to, but considering the point of living beings is to live, rather than to die, that only makes sense.
The only good thing, however, is that if death is the end, that also means you KNOW that your existence is finite. I find that far more uplifting than the concept of some infinite duration of would could only become a torment in the long run.
Besides, don't think of how much your life sucks, or how little time you have left. Think of how lucky you are for the little time you have had.
Consider how unlikely it is that you ever came to existence, considering the gazillions of people who could theoretically have been there instead of you (just take into account the genetical possibilities, then consider your life as a whole and the events that essentially made you who you are, and without which you *would* be a different person -- even so, you could have died before birth, or your parents could never have met).
Your life is an incredible privilege, and you should be happy to have tht privilege. And if you know you are going to die soon, there's no point in looking at other people who get to live longer -- being disappointed or jealous that you don't get to live as long (or weren't born with the same privileges -- physical OR material) doesn't make you live longer or make you any happier, so it's a waste of time.
There's always someone who had a longer life, or had more sex, or more friends, or more action, or seen more of the world than you have.
Of course I'm not saying you shouldn't look beyond the rim of your plate or anything like that. The meaning of life is the pursuit of happiness, and that includes striving for something better.
But greed an jealousy won't get you happiness, that's all I'm saying.
And that's the meaning of life in a nutshell.
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EDIT: To the above poster... GTFO. The big bang wasn't unlikely. If it happened, it was bound to happen. Probability only comes into play when you analyse the possible consequences of something and don't know all the variables (of course we may never know all the variables, blame Heisenberg for that bit of knowledge).
Also, the notion of an incomprehensible god usually implies that you only think of that god as the explanation for something that you do not fully comprehend. That means your god only lives in the gaps of mankind's understanding of how the world works. And that living space is shrinking rapidly.
If you wish to think of any such supernatural (i.e. irrational) being, be it god, Satan, Santa, pixies, or the easter bunny, as the cause of the Big Bang, that's fine.
But please don't blame the state of the world as-is (x-ref: creationism / intelligent design) or the happenings in people's daily lives on him.
Trust me. If God was responsible for all the good and evil in the world, God would be one hell of a sadistic asshole.
Only one thing is sure: God is a woman and her name is Eris.
All Hail Discordia.
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EDIT: Oh, and if you decide rationality is too boring and DO want to go with the fairies and pixies, please DO pick a religion that is a bit interesting.
Nothing personal, but Islam, Judaism and Christianism just totally lack humour. Which is amazing, because Roman Catholicism would have the potential for quite some fun -- especially if you think about the actual accounts some of the stories describe. The whole "bring out your visitors so that we may know them" thing is just gold.