I think the are where the missile striked in NYC would be over Central Park likely. With the other 5 boroughs being wrecked to hell. I can see some civilization trying to restart itself in the ruins of Staten Island or the Bronx considering they have the most direct land routes.
New York would be my all time favorite location for a fallout game if it was done correctly. I was thinking you could have boats transporting you to different parts of the city because the bridges would be so fucked up. I imagine the boats taking you to ports in south Manhattan, Brooklyn and Staten Island. I'd love to explore the ruins in and around Wall Street, read about all of the horrible shenanigans they got up to before the bombs hit. They definitely couldn't do the entirety of NYC, so they'd have to section off parts of it, like the areas that have become massive craters and are just completely uninhabitable. Man, I'd love that, I really hope that bethesda doesn't just make a wimpy DLC that takes you there, I really want someone to make a full game out of it.