Nah, PoS caused Van Buren to be postponed, eventually Interplay ran into financial difficulties (partly due to the failure of PoS) and it was shelved indefinitely. Then Beth bought the IP and did all that shit, but PoS was the beginning of the end (or Tactics was depending on your opinion).
Don't you diss Tactics! Besides the lack of RP/speech and such i loved it. Would have been great to see another Fallout with the same looks but a lot more RPG. Or heck even F1-2 made in the same engine.