Mac said:If any of you old hands have tips I would be very much appreciative of the help.
Yeah. Don't drink the glowing water.
Sorry... another "in joke," this time a reference to dialogue with a character from the first game.

On a more serious note: I'd be interested in knowing, after you play both games, which one you like more.
Like many here, I feel that F1 did a better job at getting the "setting" right - it was more desolate, hopeless, and mature. The fact that there was less civilization in general (by F2, the Cali area has started to "redevelop" a bit, and we even see politics rear its ugly head), helped with the whole "blown back to the stone age" feel.
Regardless of this fact, however, I find that I play F2 much more often. I'm not entirely sure why, but I think it may have to do with the lack of a time limit, and the larger number of areas to explore.
Do play Fallout 1 first, though. I think it makes things more enjoyable to go through in order.
Something to keep in mind about Fallout is that it doesn't take place in "our future," but, rather, in the future of an alternate universe, where the Cold War never ended, Communism never "fell," different technologies developed, and the U.S. remained mired in a 1950s era "Red Scare" mentality. Check around on NMA, and other Fallout sites, for info on the background of the Fallout universe.