One of my dream games (I have a few different kind of games I wish someone made) would be a Post Apocalyptic, isometric RPG. Now what would make it special would be that the action would happen mostly in just one randomly generated (quite large) settlement. At the start of the game we could make our character and then choose the role in that settlement we would be playing (we could choose any role that would exist in that settlement, from homeless to mayor, from store owner to police officer, from bartender to doctor, etc). The settlement would be surrounded by an unforgiving wasteland and would only get heavily fortified caravans on specific days. Anyone trying to adventure to the wasteland by himself would die an horrible death. Any normal character would not stand a chance if he fought a police officer (police would be heavily armored and use the most powerful weapons).
We would have to do our job in that settlement or we could change jobs. At random the settlement would be attacked by raiders or wasteland critters. The objective would be to try and make the settlement survive for as long as possible and make our character be successful in whatever role it has, it would be possible to lose his position if the player didn't do a good job and then have to find a new job or risk being a homeless person.
I think it could be an interesting and relaxing game for when I don't feel like playing something more action-y or something.