Again, some positive bits, some negative. I don't really care about the weather and the other things that don't affect gameplay. Dialog sounds good, the new AI stuff also good (but we all know what happened the last time Beth talked about AI) and the faction things are nice. I don't mind the dungeons and fast travel either way, and at least some non-humans can be reasoned with.
Combat still sounds mainly crap, invincible NPCs are disappointing though not entirely unexpected. The trait/perk merging and strange leveling sound weird but I don't really know enough about the balancing and stuff to declare it crap just yet. Oh, and how the hell does a shirt increase your barter skills?
The bar screen looks pretty nice, the others are the same old combat/pipboy stuff.
Still doesn't strike me as a sequel to Fallout, but sounds like a good game.