You could take some roads off the beaten path by creating unique, personal goals for each character. Most of these won't be recognized by the game, but it's fun anyways.
For example, on my last play through I role played someone whose family was royally screwed over by the NCR, specifically Kimball. Rather than scorch the embassy or wipe out Camp Golf, I played it slick by gaining NCR favor until You'll Know When it Happens. My character's story was effectively over after I blew Kimball to pieces with Annabelle - dashing off to the Mojave Outpost was just an optional epilogue.
For example, on my last play through I role played someone whose family was royally screwed over by the NCR, specifically Kimball. Rather than scorch the embassy or wipe out Camp Golf, I played it slick by gaining NCR favor until You'll Know When it Happens. My character's story was effectively over after I blew Kimball to pieces with Annabelle - dashing off to the Mojave Outpost was just an optional epilogue.