Victor Presper was born and raised in the area formally known as Shady Sands, now known as NCR. He spent many of his years as a scientific adviser to President Tandi before his disillusionment settled in – a disillusionment fueled by the Caravan houses that ate away at NCR. He and the others effectively grew frustrated with Tandi, the BoS, the caravans, and everyone else. They just want to start over by wiping the slate clean. Presper needed military help, so he wrangled all of the pissed off NCR Army people into helping him. Even though the NCR Army was winning the war against the Brotherhood of Steel, morale was really low due to the sheer number of causalities they suffered. For every Paladin the NCR took out, they would lose ten or more dumb yokels with leather armor and a bad rifle. The army was also really tired of fighting against powder gangs, which were essentially created because NCR didn't have enough money to pay its railway workers.
Presper noticed a report to NCR by a scientist named Goddard noting the locations of old-world power facilities and sent him out again to investigate certain areas in the old America's southwest. After Goddard returned, Presper and a small team of soldiers investigated Boulder Dome, finding it in need of repair but containing excellent labs and a fully-functioning ZAX unit. When his breaking point finally came, Presper became determined to find a way to rid the world of chaos and human impurities, and discovered his savior in the Limit 115 virus. Through extensive research, Presper discovered the history of Limit 115 and its genocidal potency, and also discovered a viable means to cleanse the world. Using ULYSSES, the Tibbets quarantine prison, and a ballistic satellite known as B.O.M.B.-001, the way to human planetary domination and order became clear. He needed to get to B.O.M.B.-001 and use the nuclear weapons to clean the filth and wretch that currently occupied the surface.
Over the next few years Presper invited or sent scientists and students to the Boulder Dome, where he explained his idea to remake civilization. Those who refuse are put in cold sleep, using technology the original Dome scientists developed to aid space travel. Presper knows he can use the CODE (Challenge, Opportunity, Discipline, Ethics) technology developed there to convince them to help him when the time is right.