Since I could only vote for one, I picked The Last Guardian because I enjoyed Shadow of the Colossus so much.
If I could vote again, here would be the order:
1st: The Last Guardian
2nd: Fallout: New Vegas
3rd: Dead Space 2
I'd also put a vote in there for Metroid and Zelda, but I still don't own a wii, so what's the point?
But to be 100% honest, there's nothing here that I'm totally psyched about. I can easily wait for them all to hit the $20 bargain bin. The only two games I expect to be purchasing at full retail in the near.. far.. whatever future this list is referring to, are Starcraft II (already pre-ordered the CE) and Diablo 3.