I wonder, why would it ruin the setting to put it in Europe? Europe is pretty diverse, and would allow for some interesting things, to see how the world affected Europe etc.
However, I would still like to keep it around the original places, just to see what happened afterwards.
I would like something fresh, as well, though. They did a relatively good job for the placing of Fallout 2, it was new, but had some old places as well.