Some quick impressions based on playing very little of the opening area:
1. Unlike SPECIAL, you can't decrease an Attribute lower than 3 which does limit the builds a bit IMO.
2. You also can't increase a skill during creation higher than 15. You are given 135 skill points to spend. It does list what I suppose is an effective skill level in brackets next to your actual skill level. Picking certain feats increases the number in brackets, not the points you put into the skill.
3. You can also select 2 feats. These are special skills that you have to activate to use I guess. Though there do seem to be some passive ones like Snooping where it'll increase your Perception by 3 for purposes of spotting secret doors and the like.
4. The graphics are the typical Fallout isometric viewpoint. The graphic style reminds me of Crusader:No Remorse a bit. It's a pretty clean look, though not particularly detailed, which is fine since it's an indie game and all.
5. There is a field-of-view fog-of-war which I suppose is based on your character's perception. Things aren't in view past a certain distance. For instance, there's a character at the back of this large common area and I don't seem him until I get close enough and he's within my field-of-view.
6. Based on a conversation with an NPC, there is a location in the game called "The Hub". :p
That's all I got so far. Haven't really done any of the story yet though I have arranged a side mission with a shadowy-looking NPC. :p
EDIT: There are also Psionics. To use them requires training. Just had my first training session. Was interesting. :p
And that's all I have time to play for now. Got other stuff to do.