NotAcasul
meanie
21 : the Institute needed pure DNA Is Shaun's DNA pure ? Hell no. The boy was in his mother's arms, in sight of a freaking nuclear explosion before he was frozen. Now, let's remind us of some basic notions of physics : gamma radiations travel at the speed of light. At the very second you see the flash of a nuclear bomb, your body is ALREADY bathing in Gamma Radiations, which are responsible for causing DNA mutations. So, if anything, Shaun is more irradiated than most of the survivors who managed to hide underground when the bomb exploded. Especially when you see the glowing sea and realize how dirty this bomb was. And let's not forget that Shaun was fed by a robot powered by an atomic battery, who regulary changed his diaper and made his food, mostly made with highly dangerous isotopes. The whole thing, surrounded by nuclear cars. The whole thing, while being born from a guy who was on the front of a war that used massive chemical weapons, fat mans etc. Too bad for the Institute's experiments, I guess.
Hol up
It's not the gamma radiation that makes someone less pure. It's the scattered bits of FEV from the targeted facilities. Which comes after the Great War. Remember Saul, one of the best companions? He became a ghoul after the bombs fell. The Glowing Sea was a shit-hole because: hidden nuclear facility containing hundreds (thousands?) of nuclear weapons, multiple nuclear reactors and a high-level surveillance facility http://fallout.wikia.com/wiki/Abandoned_shack_(Fallout_4). The Chinese would have a very good reason for attacking it, much more than Boston.
22 : Synth can't remember the Institute, because security protocols wipe these memory out. Sure thing. Except for Glory, right ? She remembers the Institute very well. Except for Harkness, too ? You just have to tell him he's a Synth to remember everything about his past. Now, you're telling me than in sixty years, not a single synth was captured and tortured to give the Institute's location?
Perhaps the Institute programmed them to not give out that kind of information?
18 : There are super mutants at Boston. Contradiction with : all fallouts. Fallout 1 ends with the destruction of the FEV base, which was used to create mutants... And let me tell this again : pure, raw FEV doesn't produce super mutants, but monsters like Harold or the master. To engineer Super Mutants, the greatest mind of the wasteland had to grow psychic powers, unite itself with a computer and spend years of failures before even making his first super mutant. The destruction of his labs mean only one thing : that this knowledge is lost, possibly forever. There isn't a single plausible, lore-friendly scenario that explains how dumby dumb super mutants could create new soldiers on their own. Fallout 2, which happens many decades after, actually confirms that the super mutants are almost all dead. Fallout Tactics sees the midwest brotherhood stop the lat Super Mutants wave pretty easily. Depending on the ending, they end up enlisting for the Brotherhood of steel or exterminated in camps. Fallout 3 ends with the Brotherhood seizing Washington D.C., Liberty Prime, Enclave technology and choppers. If there are still super mutants in the perimeter six months after that (logically, there shouldn't have been any in the first place, but well), then it would mean that the Brotherhood has officially retreated from the east coast. Which it hasn't.
The Institute have 200+ years to perfect their formula and even then it isn't perfect. All the Super Mutants have been produced by the Institute. I'd bet that the Institute tried this right after the bombs fell.
Everything else is good.