Well, I finally created an account, after lurking since mid- 1998.
It was these five gameplay videos that pushed me into making my account; they look flat out sensational. Unlike a lot of other posters, I adore the selection of music. I'm sure you can toggle your radio on and off, and when it couldn't be heard in the demo, the non- diagetic sound, especially in the town of Megaton, was extremely well done, very remenisce of the original Fallout games. As for the other stuff, i'm a sucker for the old 50s sounds anyway, and it reminded me of The Inkblots intro score from Fallout 2. A good thing.
One post in particular caught my attention: Brother None's. Well balanced views and whatnot, but I thought the ghoul's voice was just fine. The voice acting on the whole I felt was far superior to Oblivion's. Also, the lack of a reaction to the ghoul blowing up was due to the fact that the guard wasn't standing on the other side of the wall. It was an intercom, and therefore, the guard would've been some 500 feet away, inside the building. Also, the explosion happened whilst the guard was talking, and the ghouls hands were scrabbling around on his own body to locate the grenade, so his finger was not pressed on the intercom, making the explosion go unnoticed to all but the player, and the unfortunate recipient.
Overall, an incredible first impression for me. I'm looking forward to this more than I have any other game for years.