Vault 33 being in Santa Monica doesn't really make much sense. Its entrance is out in the open, meaning the Master's Army should've clearly stumbled across it, but chose not to raid it? Considering how the Lieutenant gets hard when he sees a prime normal: the Vault Dweller brought to him at Mariposa, it seems hard to believe they would pass on the opportunity to raid a vault full of them, literally on their doorstep by the Cathedral.
Also, the Brotherhood really shouldn't have a military of this size. As far as we're aware, they're still sqaullering in bunkers like hermits due to their defeat in the NCR-Brotherhood war, so how on earth they were able to mass produce or find vertibirds and then create an airship of the same design and scale of the Prydwen is beyond me. Even if they were to broker a peace with the NCR, it seems unlikely the NCR would allow the Brotherhood to expand their military to this extent given what happened last time.
The general lack of the NCR in the show is worrying. The Boneyard is now... Megaton? Even though the NCR are actively rebuilding it and the Followers have a university there by the events of New Vegas?
It's almost as if this show was written by people who have played the Bethesda games, are unware that lore exists in the west coast and then believe the west coast is the perfect setting to introduce their own story, which wouldn't really surprise me.
Slowly coming the conclusion that I really shouldn't care about any of this anymore as the lore has been fucked to shit long before this show was announced, but hey-ho.