I find the leader of the Thieves Guild in FO 1 to be hilarious. I cant remember what he says now but it had in stitches , summit involving the word bugger and bloody.
"bloody fine job getting through our defences, mate! Toss me your name!"
....
"Now lets get the other formalities taken care of, shal we? What the bloody, bloody, bloody hell are you doing here?"
....
"But if you even think of ratting us down to the cops we'll be gone before you even know it(or something along those lines), but enough gloom, cherio, good luck and tatta!"
A talk with the Wright kid after beating the Enclave:
" Kid:Are you gonna delete us from yer hard drive now that you finished the game?
Chosenon't worry, little one. You won't feel a thing.
K:Will we dream?
C:Beats me. I don't seem to dream, so you probably don't either. Life's a bitch, huh?"
I found this in one of the Fallout game's Readme.txt:
"War, war, never changes...
And it can be really rather unpleasant. After the bomb had dropped, toilet paper and those funny little packets of soap that you find in hotel rooms became very difficult to find."