I edited my post after I posted (currently at work). Please review, also my intention is not to be inflammatory but to participate in the debate. However my request for additional information is still valid, please participate.
Thanks. To cover this:
1. Reusing FEV isn't particularly original, but it isn't a game breaker for me. It was already reused in Fallout 2 to make FEV Curling-13, so it's not without precedent (not particularly original, much like the whole Enclave and the dumb Vault Experiments, but it happens).
2. You're not going to see "any indication that they moved the West Tek FEV any were else" because at the time they didn't know they'd be making sequels. However, note that it's not an absolute statement. According to
the source, Major Barnett, the military liaison at West Tek (and only West Tek) ordered the research moved to Mariposa. A Major wouldn't be able to move all FEV research in existence to Mariposa, so that's still open ended.
3. I quoted ZAX to show that the cure is theoretically possible. Did you read the entire reply or just the first word ("No")? Because it clearly states that a virus that re-infects with the original DNA could succeed, but one would also have to remove the FEV. Which is a trivial matter compared to rewriting an entire genome.
I'm well aware that things like this exist, and that they do have some basic fleshing out.
I found the things Strong said to be interesting as well, and they would have been even more interesting if Supermutants had social structures, tribes, leaders, and motive to fight you.
But since they never went in to much detail in to Supermutant culture beyond Strong it feels like wasted opportunity, adding slight interest to them through the words of one companion, while making that the only depth to them.
You and me both, but it's not like they didn't think about it. Everyone prioritizes development and super mutants weren't a core part of it, just a side interest (much like the muties were in Fallout 2, mostly just random mooks to gun down in Central and flavor characters, with one companion).
I'd say it detracts from them.
In previous Fallout games Supermutants had actual reasons to be fighting you. The Fallout 1 Supermutants because they were followers of an ideology that was focused on uniting humanity under a common cause, the Fallout 2 Supermutants because they were territorial after taking over Mariposa from the Enclave due to being used as mining slaves, the Fallout New Vegas Supermutants are under the influence of a manipulative, crazy dictator.
Bethesda reduces them to "Kill Human, We big strong warriors, let's suicide bomb ourselves", instead of giving them actual depth and reasons to fight you.
That's your prerogative. I don't consider it a detraction because these aren't the same super mutants. They're distinct subtypes of humans made by people who either didn't know how to make it work (Merrick at V87) or didn't care (Institute). Different origins, different creatures, different modes of operation.
People reject chemo because it has a very low chance of actually being helpful(IIRC there's something like less than a 3% chance of having a positive impact)
I wholeheartedly recommend not listening to quacks.
https://sciencebasedmedicine.org/chemotherapy-doesnt-work-not-so-fast-a-lesson-from-history/
http://scienceblogs.com/insolence/2011/09/16/two-percent-gambit-chemotherapy/
Basically, chemo effectiveness varies, but it's generally one of the most effective ways at reducing mortality rates and/or removing cancer.
FEV we're talking about a surefire way to get rid of the cancer. I genuinely don't see why Shaun wouldn't.
That's what he says, there are ways. But he doesn't want to go to these extremes. Simple as that. Maybe he wants to die as human, maybe he wants to make way for you, maybe he doesn't want to become a monster.
The Master commits suicide when his dream is destroyed by you, despite the fact it could be reliably salvaged. You could just as well say that you genuinely don't see why the Master would do that.
Coffin Willie: One minor mistake, not an entire questline. Plus it could very well be the case that it felt like months to Willie. Billy there's no ambiguity whatsoever, he says he's before the bombs, Bullet says Ghouls don't need to eat or drink, there's no possible justifications for it.
You do realize that you're now just making an excuses for Coffin Willie, right? Why won't you make the same for Billy (hell, even the name fits)? Bullet's a raider with no real background in biology... Not to mention the Slog, man.
Reservation: Incomplete. They could have figured out the pee poop thing in the meantime.
It does show developers confused af.