A couple ideas on the topic:
1) Shadowrun First-Person RPG- Something along the lines of Fallout and Deus-Ex classic. No lame shooter online shit. I want to see a Cyberpunk city with next-gen graphics. The Deus-Ex remake dumbed down things too much though, so I am not happy about that. I am afraid a remake of Shadowrun would succumb to a similiar fate.....
2) Earthbound for Wii) I loved the classic Earthbound JRPG series for NES and SNES, but they are not as popular in the States. The humor was always really good for a RPG and it was set in modern times, so cars,aliens,psychic power and that sort of thing, as opposed to dragons and swords. Nintendo needs to support more of their titles like this I think.
To be perfectly honest though I would like to see more original titles than remakes or reboots.